Ōkuma Tomohide (大熊朝秀, 1517 - April 3, 1582) was a Japanese samurai of the Sengoku period. He served the Uesugi clan, but later switched allegiances and became a retainer of the Takeda clan of Kai Province. He died with Takeda Katsuyori at the Battle of Temmokuzan.
Tomohide's descendants became the chief retainers of the Sanada clan.